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Lymphangioleiomyomatosis (LAM) is a low-grade destructive metastasizing PEComatous tumor 1 resulting from the proliferation of LAM cells in the lung, kidney and axial lymphatics. The disease is caused by mutations of the TSC2 or TSC1 genes and is more commonly sporadic rather than inherited. Cystic lung disease (CLD) is the most frequent.
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Background: Enhancing tumor-specific T-cell immunity by inhibiting programmed death ligand 1 (PD-L1)-programmed death 1 (PD-1) signaling has shown promise in the treatment of extensive-stage small-cell lung cancer. Combining checkpoint inhibition with cytotoxic chemotherapy may have a synergistic effect and improve efficacy. Methods: We conducted this double-blind, placebo-controlled, phase 3.
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Lymphangioleiomyomatosis (LAM) is a condition that affects the lungs, the kidneys, and the lymphatic system. The lymphatic system consists of a network of vessels that transport lymph fluid and immune cells throughout the body. Lymph fluid helps exchange immune cells, proteins, and other substances between the blood and tissues.
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Lymphangioleiomyomatosis (LAM) is a progressive, cystic lung disease in women; it is associated with inappropriate activation of mammalian target of rapamycin (mTOR) signaling, which regulates.
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The Tomahawk ( / ˈtɒməhɔːk /) Land Attack Missile ( TLAM) is a long-range, all-weather, jet-powered, subsonic cruise missile that is primarily used by the United States Navy and Royal Navy in ship and submarine-based land-attack operations.
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DESIGN GUIDE Part 2: Design Guide for Manufacturing Tlam Substrates The Design Guide Part 2 provides details for designing Tlam substrates for manufacturability, and for addressing the associated manufacturing controls and evaluation issues.